Because of a spontaneous deletion in one of the exons, this strain’s natural antioxidant enzyme, nicotinamide nucleotide transhydrogenase (NNT), has been completely disrupted in terms of protein expression. The reduced glucose clearance and resting glucose levels are caused by this mutation.
This model is mainly considered for – Safety/Efficacy studies, Diet induced obesity studies, Immunological studies & Inflammation responses, Fibrosis and cardiomyopathy, Heart failure models, Diabetic studies (Obesity, type-2 diabetes and associated complications), Infectious disease screening, Acute gastrointestinal infection studies
2. BALB/c
Male and female body weights approximate being equal, and both are susceptible to carcinogens. They produce kidney tumors, lung tumors, reticular neoplasms, and other tumor variations, which makes it a suitable subject for immunological and cancer recovery investigations.
This model is mainly considered for – Cancer therapy studies, Immunological studies & Antibody production, Viral defense studies, DNA vaccine studies, Anti plasmodial studies & Antifungal immune response studies
3. Swiss albino
This model is mainly considered for – Toxicity models, Efficacy Studies, Safety Studies, Multipurpose model
